What is IVF and IUI – Understanding the Difference

by May 7, 2020

If you are struggling with infertility, you and your treatment team will likely consider both in-vitro fertilization (IVF) and intrauterine insemination (IUI) in order to help you conceive. But what is the difference between IVF and IUI?

a doctor

This article will help you get back to basics and understand the differences between IVF and IUI. The following inf improve your chance of getting pregnant based on your unique fertility situation.

Intrauterine Insemination (IUI)

Intrauterine insemination, or IUI, is a fertility procedure where concentrated motile sperm are inserted directly into a woman’s uterus. IUI may be performed with or without drugs used to stimulate ovarian reserves, including Clomid, Letrozole and Gonadotropin.

For women under 38 years old, the chances of conceiving through IUI with no drugs are 1 to 5 percent. The chances of conceiving using Clomid or Letrozole are 4 to 9 percent, and the chances of conceiving using Gonadotropin are 8 to 10 percent.

Unfortunately, IUI is not appropriate for all women facing infertility, including those with severely diminished ovarian reserve, two blocked fallopian tubes or a partner with an extreme case of male factor infertility. After three cycles, IUI also begins to lose its effectiveness, at which point IVF may be required to increase your chance of getting pregnant.

IUI takes more time, has a higher chance of multiples per pregnancy and ends in more miscarriages than IVF; however, it is far less expensive and invasive than IVF, and so might be an appropriate first step for qualifying couples embarking on their fertility journey.

In-Vitro Fertilization (IVF)

In-vitro fertilization, or IVF, is a five-step process that consists of the following steps:

  1. Pre-cycle diagnostic testing
  2. Stimulation of the ovaries
  3. Retrieval of the eggs from each ovary
  4. Fertilization of the eggs in a laboratory
  5. Transfer of resulting embryos into the uterus

The effectiveness of IVF depends on the causes of infertility as well as the woman’s age. The younger the woman, the higher her odds of conceiving through IVF. However, women who start IVF sooner tend to get pregnant sooner than those who try more cycles of IUI before switching to IVF. Compared with IUI, IVF has lower odds of miscarriage, lower rates of multiples per pregnancy and produces more embryos, as well as embryos that can be frozen.

Still, some women may not want to go through IVF due to its inherently invasive nature. A full cycle of IVF requires more drugs than IUI, requires fertility monitoring and includes a minor surgical procedure (the retrieval of eggs from the ovaries).

Unfortunately, IVF can cost as much as $20,000, which may be cost-prohibitive for many patients. Thankfully, there are grants available through many non-profit organizations that can help alleviate the cost of IVF.

Hopefully, this article helps you to understand the difference between IUI and IVF. Both methods can be used as treatments for infertility, but deciding which is best for you is an inherently personal decision that should be made with your partner, your treatment team and your knowledge of infertility gained from Mira.

✔️ Medically Reviewed by Dr Roohi Jeelani, MD, FACOG and Lauren Grimm, MA

roohi jeelaniDr Roohi Jeelani is Director of Research and Education at Vios Fertility Institute in Chicago, Illinois. Dr Jeelani earned her medical degree from Ross University School of Medicine in Portsmouth, Dominica. She then completed a residency in Obstetrics and Gynecology and a fellowship in Reproductive Endocrinology and Infertility at Wayne State University, Detroit Medical Center, where she was awarded a Women’s Reproductive Health NIH K12 Research Grant. She is board certified in Obstetrics and Gynecology. Dr Jeelani has authored numerous articles and abstracts in peer-reviewed journals, and presented her research at national and international scientific meetings. A Fellow of the American College of Obstetrics and Gynecology, Dr Jeelani is a member of the American Medical Association, the American Society of Reproductive Medicine, and the American Association of Gynecologic Laparoscopists.

Lauren Grimm is Research Coordinator at Vios Fertility Institute in Chicago, Illinois. Lauren earned her bachelor’s degree from Loyola University Chicago, where she also completed her masters in Medical Sciences. Lauren has worked alongside Dr. Jeelani for the last 3 years, authoring a number of abstracts and articles in peer-reviewed journals, and presented her research at national and international scientific conferences. Lauren will be continuing her education this fall at Rush University Medical College in Chicago, IL as an MD candidate.

NEW PATIENTS 866.258.8467 (VIOS)

Order Your Mira Plus Today

Track your whole cycle and what is happening with your hormones. Get a larger fertile window (6 days) and clear insights. Let Mira take the guesswork out of tracking all fertile days and infertile days.